Publications

Publications from our UPRIME Scholars

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2025

Publications from 2025
Beetch M, Oribamise E, Jo S, Clifton B, Larson S, Hausmann A, Wong A, Akhaphong B, Morgan E, Alejandro EU. Placental mTOR signalling links mitochondrial dysfunction, nutrient transport and neonatal beta cell perturbations in mice. Diabetologia. 2025 Dec;68(12):2823-2839. doi: 10.1007/s00125-025-06542-z. Epub 2025 Oct 9. PMID: 41062808; PMCID: PMC12594745.
Cohen H, Angulski ABB, Quick JD, Kuebler TS, Thompson BR, Bauer J, Hahn D, Townsend D, Hassler JF, Hackel BJ, Lodge TP, Sham YY, Bates FS, Metzger JM. Synthetic bottlebrush block copolymer prevents disease onset in Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2025 Oct 21;122(42):e2513599122. doi: 10.1073/pnas.2513599122. Epub 2025 Oct 13. PMID: 41082666; PMCID: PMC12557544.
Parthiban P, Barrow F, Wang H, Chalise U, Araujo N, Souza-Neto F, Nguyen H, Draxler M, Pallais JP, Yucel D, Liu H, Ciske E, Fehrenbach P, Hakeem A, Lee SH, Herman A, Rothenberg ME, Dudley S, van Berlo JH, Revelo XS. Macrophage-Derived CCL24 Promotes Cardiac Fibrosis Via Fibroblast CCR3. Circ Res. 2025 Oct 10;137(9):1140-1156. doi: 10.1161/CIRCRESAHA.125.326599. Epub 2025 Sep 16. PMID: 40955564; PMCID: PMC12509456.
Moazzami Z, Queathem ED, Ma J, Chen Q, Arianti R, Aden I, Brown A, Abdulahi Z, Gu C, Chang X, Li Y, Yu H, Bartolomucci A, Panda S, Mashek DG, Kristof E, Puchalska P, Chow LS, Jia Z, Crawford PA, Ruan HB. Ketone body driven lipid remodeling supports thermogenic adaptation to fasting. bioRxiv [Preprint]. 2025 Jun 17:2025.06.13.659540. doi: 10.1101/2025.06.13.659540. PMID: 40667194; PMCID: PMC12262497.
Rozich E, Ozkurede U, Pakkiriswami S, Gemilere R, Azarin SM, Liu JC. Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia-reperfusion injury. J Physiol. 2025 May 31. doi: 10.1113/JP287770. Epub ahead of print. PMID: 40448972.
Puccini SJ, Healy CL, Harsch BA, Ahmed AR, Shearer GC, O'Connell TD. A Cell Autonomous Free fatty acid receptor 4 - ChemR23 Signaling Cascade Protects Cardiac Myocytes from Ischemic Injury. bioRxiv [Preprint]. 2025 Jan 6:2024.11.26.625260. doi: 10.1101/2024.11.26.625260. PMID: 39829927; PMCID: PMC11741238.

2024

Publications from 2024
Patterson MT, Xu Y, Hillman H, Osinski V, Schrank PR, Kennedy AE, Barrow F, Zhu A, Tollison S, Shekhar S, Stromnes IM, Tassi I, Wu D, Revelo XS, Binstadt BA, Williams JW. Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability-Brief Report. Arterioscler Thromb Vasc Biol. 2024 Jul;44(7):1646-1657. doi: 10.1161/ATVBAHA.124.320797. Epub 2024 May 2. PMID: 38695172; PMCID: PMC11208052.
Xu Y, Patterson MT, Dolfi B, Zhu A, Bertola A, Schrank PR, Gallerand A, Kennedy AE, Hillman H, Dinh L, Shekhar S, Tollison S, Bold TD, Ivanov S, Williams JW. Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGFβ. JCI Insight. 2024 Jun 13:e174746. doi: 10.1172/jci.insight.174746. Epub ahead of print. PMID: 38869957.

2023

Publications from 2023
Huang Z, Gu C, Zhang Z, Arianti R, Swaminathan A, Tran K, Battist A, Kristóf E, Ruan HB. Supraclavicular brown adipocytes originate from Tbx1+ myoprogenitors. PLoS Biol. 2023 Dec 4;21(12):e3002413. doi: 10.1371/journal.pbio.3002413. PMID: 38048357; PMCID: PMC10721186
Barrow F, Wang H, Fredrickson G, Florczak K, Ciske E, Khanal S, Parthiban P, Nguyen H, Rios E, Kostallari E, Revelo XS. Pyruvate Oxidation Sustains B Cell Antigen-Specific Activation to Exacerbate MASH. bioRxiv [Preprint]. 2023 Nov 15:2023.11.13.566832. doi: 10.1101/2023.11.13.566832. PMID: 38014163; PMCID: PMC10680643.
Patterson MT, Firulyova MM, Xu Y, Hillman H, Bishop C, Zhu A, Hickok GH, Schrank PR, Ronayne CE, Caillot Z, Fredrickson G, Kennedy AE, Acharya N, Neels JG, Chinetti G, Revelo X, Stromnes IM, Ivanov S, Bold TD, Zaitsev K, Williams JW. Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis. Nat Cardiovasc Res. 2023 Nov;2(11):1015-1031. doi: 10.1038/s44161-023-00354-3. Epub 2023 Oct 30. PMID: 38646596; PMCID: PMC11031198.
Beetch M, Akhaphong B, Wong A, Clifton B, Jo S, Mohan R, Abrahante Llorens JE, Alejandro EU. Impact of placental mTOR deficiency on peripheral insulin signaling in adult mice offspring. J Mol Endocrinol. 2023 Oct 18;71(4):e230035. doi: 10.1530/JME-23-0035. PMID: 37855320; PMCID: PMC10620464.
Wang H, Barrow F, Fredrickson G, Florczak K, Nguyen H, Parthiban P, Herman A, Adeyi O, Staley C, Ikramuddin S, Ruan HB, Jameson SC, Revelo XS. Dysfunctional T Follicular Helper Cells Cause Intestinal and Hepatic Inflammation in NASH. bioRxiv [Preprint]. 2023 Oct 12:2023.06.07.544061. doi: 10.1101/2023.06.07.544061. PMID: 37873316; PMCID: PMC10592647.
Chapoy Villanueva H, Sung JH, Stevens JA, Zhang MJ, Nelson PM, Denduluri LS, Feng F, O'Connell TD, Townsend D, Liu JC. Distinct effects of cardiac mitochondrial calcium uniporter inactivation via EMRE deletion in the short and long term. J Mol Cell Cardiol. 2023 Aug;181:33-45. doi: 10.1016/j.yjmcc.2023.05.007. Epub 2023 May 23. PMID: 37230379; PMCID: PMC10524693.

2022

Publications from 2022
Dolfi B, Gallerand A, Firulyova MM, Xu Y, Merlin J, Dumont A, Castiglione A, Vaillant N, Quemener S, Gerke H, Stunault MI, Schrank PR, Kim SH, Zhu A, Ding J, Gilleron J, Magnone V, Barbry P, Dombrowicz D, Duranton C, Wakkach A, Blin-Wakkach C, Becher B, Pagnotta S, Argüello RJ, Rantakari P, Chakarov S, Ginhoux F, Zaitsev K, Kim KW, Yvan-Charvet L, Guinamard RR, Williams JW, Ivanov S. 
Unravelling the sex-specific diversity and functions of adrenal gland macrophages. Cell Rep. 2022 Jun 14;39(11):110949. doi: 10.1016/j.celrep.2022.110949. PMID: 35705045; PMCID: PMC9210345.
Hahn D, Quick JD, Thompson BR, Crabtree A, Hackel BJ, Bates FS, Metzger JM. Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers. Skelet Muscle. 2023 May 19;13(1):9. doi: 0.1186/13395-023-00318-y. PMID: 37208786; PMCID: PMC10197332.